Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study

Background and aimsPlatelet count (PLT) is a predictor of metabolic inflammation-related disorders. Platelets can release prochemerin, which acts as link between coagulation inflammation innate adaptive immunity. The causal effect PLT circulating chemerin level has not been elucidated.MethodsNondiabetic participants with samples in the Taiwan Biobank were recruited for genome-wide association study (GWAS) based on (17,037 participants) levels (3887 participants). A bidirectional Mendelian randomization (MR) was conducted to determine levels.ResultsFor GWAS PLT, 11 gene loci found have significance. For levels, two loci, RARRES2 HLADQA2-HLADQB1, Age, sex, body mass index, leukocyte count, hemoglobin, mean blood pressure, hemoglobin A1C, serum total bilirubin, aspartate aminotransferase, triglyceride, low-density-lipoprotein cholesterol estimated glomerular filtration rate, be independently associated through stepwise regression analysis. MR revealed weighted genetic risk scores (WGRSs) significantly by using two-stage least-square method multivariate analysis (p = 0.0031), no significant WGRSs noted. Sensitivity further violation exclusion-restriction assumption PLT-determining genotypes levels.ConclusionsThrough analysis, our data that determined PLT. Circulating intermediates future